Day: March 30, 2023

I have been longing for the tree of life that is in the book of Revelation. It has fruit each month, 12 different kinds, and the leaves are for the healing of the nation. I’m sure they are low oxalate!

I think I figured out why the 1980-ish study found that plantain had only 1 mg of oxalate, but new data is closer to 524 mg of oxalate. It is the increased use of glyphosate. Glyphosate is not just on our fruits and vegetables that aren’t organic. It is in the soil. It can stay in the soil for many years, but decreases as plants suck it up through their root systems. Then the plants metabolize the glyphosate to….oxalate!!! They aren’t naturally poisonous. They are trying to protect themselves from glyphosate. We also metabolize glyphosate that we consume to oxalate! There are some bacteria that can eat oxalate, but most people do not have this healthy oxalobacter formenges. Maybe it died off with glyphosate increases? I think so.

In my opinion, So our heavenly Father didn’t intent for us to have this poison in our foods. I do know of one lab, Unlocked Labs, who is working on turning on genes in bacteria so that they eat oxalate. That’s interesting. I sent them the hypothesis about NAD dependent vitamin A metabolism and how oxalate is inhibiting NAD recycling. We shall see how that goes.

This is the metabolism of glyphosate in the human body. The body can make two products that cause damage to vitamin A metabolism. Oxalate and Formaldehyde. Oxalate impairs LDH causing decrease in NAD needed for retinol and retinal metabolism to retinoic acid. Formaldehyde puts burden on Aldehyde dehydrogenase that is needed for retinal to retinoic acid conversion.

Water quality matters. This is shows that hard water (water treated with chemicals and minerals such as the water that we get from the city) will cause glyphosate to remain metabolized for many years. Normal water will result in glyphosate breaking down into metabolites that can still harm people if they are B6 or Thiamine deficienct, but it will degrade faster and not persist in the environment.

There’s so much more research on this persistent poison, but I think I will stop here and make some recommendations.

1. Avoid the dirty dozen (EWG is a good place to start)
2. Avoid wheat, corn, oats, and soy if not organic
3. Realize that the oxalate in plants is higher now likely due to the fact that glyphosate is so abundant in our soil and water supply
4. Forgive the dietitian who made the bad handout for not realizing this, but send her this blog.

This is a quick hypothesis on the need to correct the ability to catabolize retinoic acid (final irreversible product of vitamin A metabolism). This hypothesis is not intended to diagnose, treat, or cure a disease. It is only written for to inform. Please consult with your personal healthcare practitioner before making any changes. I am not a doctor. I am dietitian with a quirky set of skills. – Meredith Arthur, MS, RD, LD

Retinoic acid (RA) has to be catabolized and removed from the body or levels may go to high. Some symptoms that I contribute to high retinoic acid include, nausea, peeling skin, burning sensation of the skin, headaches, fatigue,

This breakdown of RA requires CYP26. There are no known inhibitors of CYP26…yet…but it does require NADPH. This can be made from NAD. In a low NAD state, you won’t have enough NADPH to be able to metabolize retinoic acid. As you work on changing habits that decrease NAD, this NADPH should improve, BUT there is a chance that you are over using all cytochrome P450 enzymes resulting in a burden on NADPH. This could lead to increased levels of RA. High RA can poison a person (think Accutane poisoning). So, I’m working on figuring out how to maximize this NADPH dependent removal of RA.

After it is metabolized by CYP26, the products of RA must go through the glucuronide pathway. There are many substrates that use this pathway. Stevia is one of them. All stevia glycosides are detoxified by this pathway. Monk fruit is also a glycoside, and so uses glucuronidation to be removed from the body. Many drugs use this pathway. So this is another possible inhibitor of properly removing retinoic acid from the body.

There is a vitamin A toxicity group on facebook that has some good information about maximizing these pathways. As I explore this more, I will add what I think is valuable information to this post. So far, these are the most important changes to make to diet (consult your healthcare provider before making changes):

• increase egg yolks to four per day (Andrew Baird from the Vitamin A toxicity group recommends going slow with eggs and starting with one per day https://www.facebook.com/groups/3033243886748451/)
• decrease sweeteners such as monk fruit and stevia
• work on daily bowel movements, but not with Miralax. Magnesium bicarbonate may help as the bicarbonate also triggers mesothelial cells to make acetycholine independent of vagus nerve stimulation. Acetycholine is the major neurotransmitter of the gastrointestinal tract. I used to use Magnesium citrate with Zoey, but just yesterday one of my “treasures in heaven clients”, Meagan, told me she makes magnesium bicarbonate to increase magnesium levels. Well, I said, “You also just helped your GI tract move.” We learned from each other. Life is a team effort and God brings people together for the good of each other.
• consider Taurine supplement to help with bile acid production
• avoid glyphosate as this overloads cytochrome P450 and ties up NADPH in detoxifying it (Go Organic. Avoid non-organic wheat, soy, oats, corn. ) Check out EWG dirty dozen. https://www.ewg.org/foodnews/dirty-dozen.php
• consider supplementation with calcium-D glucurate to support glucuronidation pathway (Thanks, Oskar for piping in on the Vitamin A toxicity group.)
• DO NOT consider inositol to support the pentose phosphate shunt pathway that helps to make NADPH. I will make a post soon on why you should avoid inositol supplements in detail. However, to give a short explanation, inositol can impair the production of cardiolipin by posttranscriptional inhibition of enzymes in this pathway. I believe this production is already impaired by retinaldehyde accumulation that complexes with ethanolamine leading to A2E formation (lipofuscin). This decreases the availability of CDP diacylglycerol which is a precursor for cardiolipin. When cardiolipin levels decrease in the mitochondrial membrane, this can cause oxidative stress and cell death. Having high vitamin A status alone can cause this process by stealing a source of CDP diacylglycerol needed for cardiolipin production, but adding in inositol can completely inhibit this pathway. In fact, A2E accumulation in the eye actually causes damaged to cytochrome C oxidase leading to oxidative stress. Again…longer post coming soon.

source for MgHCO3 recipe https://wellnessmama.com/health/magnesium-bicarbonate/

Meagan recommends checking on Musclesandmotherhood on instagram for recipes and info about MgHCO3 https://www.instagram.com/_musclesandmotherhood/

This post was reviewed by Jenny Jones, PhD, human molecular genetics. I want to make sure that whatever I share with you has at least two critically thinking minds working on a problem. <3