Sulfite toxicity in sulfite oxidase (SUOX) or molybdenum cofactor (MoCo) deficiency can lead to neurotoxicity due to the excessive production of s-sulfocysteine (SSC). It’s possible to have a genetic predisposition to decreased SUOX and/or MoCo. However, something to consider is that the current state of our environment can lead to what I like to call “endgame enzyme burnout”. Hypoxia, infections, and other “modern-day lions” can lead to increases in sulfite via the HIF-1alpha pathway induction of cysteine dioxygenase. Neutrophils produce sulfite in response to infections. As sulfite levels increase beyond the capacity of SUOX, sulfite alters glutamate metabolism and brain bioenergetics.
7 PATHWAYS FOR GLUTAMATE CAN ENTER
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(PDF) Gephyrin: a central GABAergic synapse organizer
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